PCNA monoubiquitylation and DNA polymerase η ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae

7,8-Dihydro-8-oxoguanine (8-oxoG) is an abundant and mutagenic DNA lesion. In Saccharomyces cerevisiae, the 8-oxoG DNA N-glycosylase (Ogg1) acts as the primary defense against 8-oxoG. Here, we present evidence for cooperation between Rad18–Rad6-dependent monoubiquitylation of PCNA at K164, the damag...

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Huvudupphovsmän: van der Kemp, Patricia Auffret, de Padula, Marcelo, Burguiere-Slezak, Guenaelle, Ulrich, Helle D., Boiteux, Serge
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2009
Ämnen:
Genome Integrity, Repair and Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677869/
https://ncbi.nlm.nih.gov/pubmed/19264809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp105
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