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dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae

We identified a viable allele (dut1-1) of the DUT1 gene that encodes the dUTPase activity in Saccharomyces cerevisiae. The Dut1-1 protein possesses a single amino acid substitution (Gly82Ser) in a conserved motif nearby the active site and exhibits a greatly reduced dUTPase activity. The dut1-1 sing...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Guillet, Marie, Van Der Kemp, Patricia Auffret, Boiteux, Serge
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440884/
https://ncbi.nlm.nih.gov/pubmed/16617146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl139
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