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A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter
DNA-binding domains with predetermined sequence specificity are engineered by selection of zinc finger modules using phage display, allowing the construction of customized transcription factors. Despite remarkable progress in this field, the available protein-engineering methods are deficient in man...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677679/ https://ncbi.nlm.nih.gov/pubmed/11433278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/90264 |
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