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A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

DNA-binding domains with predetermined sequence specificity are engineered by selection of zinc finger modules using phage display, allowing the construction of customized transcription factors. Despite remarkable progress in this field, the available protein-engineering methods are deficient in man...

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Detalhes bibliográficos
Main Authors: Isalan, Mark, Klug, Aaron, Choo, Yen
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677679/
https://ncbi.nlm.nih.gov/pubmed/11433278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/90264
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