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Repression of the HIV-1 5′ LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

Zinc finger domains are small DNA-binding modules that can be engineered to bind desired target sequences. Functional transcription factors can be made from these DNA-binding modules, by fusion with an appropriate effector domain. In this study, eight three-zinc-finger proteins (ZFPs) that bound HIV...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Reynolds, Lindsey, Ullman, Christopher, Moore, Michael, Isalan, Mark, West, Michelle J., Clapham, Paul, Klug, Aaron, Choo, Yen
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149881/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12574502/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252770699
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