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PLAQUE-BEARING MICE WITH REDUCED LEVELS OF OLIGOMERIC AMYLOID-β ASSEMBLIES HAVE INTACT MEMORY FUNCTION

The amyloid-β (Aβ) protein exists in the aging mammalian brain in diverse assembly states, including amyloid plaques and soluble Aβ oligomers. Both forms of Aβ have been shown to impair neuronal function, but their precise roles in Alzheimer’s disease (AD)-associated memory loss remain unclear. Both...

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Detalhes bibliográficos
Main Authors: Lesné, Sylvain, Kotilinek, Linda, Ashe, Karen H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677385/
https://ncbi.nlm.nih.gov/pubmed/18155846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.10.054
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