Valproic acid causes dose- and time-dependent changes in nuclear structure in prostate cancer cells in vitro and in vivo

INTRODUCTION: Histone deacetylase inhibitors (HDACIs) such as valproic acid (VPA) are promising anti-cancer agents that change the acetylation status of histones and loosen the chromatin structure. We assessed nuclear structure changes induced by VPA in prostate cancer (PCa) LNCaP, CWR22R, DU145 and...

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Main Authors: Kortenhorst, Madeleine S. Q., Isharwal, Sumit, van Diest, Paul J., Chowdhury, Wasim H., Marlow, Cameron, Carducci, Michael A., Rodriguez, Ronald, Veltri, Robert W.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676893/
https://ncbi.nlm.nih.gov/pubmed/19372553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1076
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