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Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

Tumor suppressor p53 is an attractive cancer therapeutic target because it can be functionally activated to eradicate tumors. Direct gene alterations in p53 or interaction between p53 and MDM2 proteins are two alternative mechanisms for the inactivation of p53 function. Designing small molecules to...

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Detalhes bibliográficos
Main Authors: Shangary, Sanjeev, Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676449/
https://ncbi.nlm.nih.gov/pubmed/18834305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094723
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