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Bortezomib induces osteoblast differentiation via Wnt-independent activation of β-catenin/TCF signaling
Inhibition of Wnt/β-catenin/T-cell factor (TCF) signaling induces proliferation of mesenchymal stem cells and/or suppresses their differentiation into osteoblasts (OBs). Osteolysis in multiple myeloma (MM) is related to the suppression of canonical Wnt signaling caused by DKK1, a soluble inhibitor o...
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| Hoofdauteurs: | , , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society of Hematology
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676089/ https://ncbi.nlm.nih.gov/pubmed/19196662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-174300 |
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