Bortezomib induces osteoblast differentiation via Wnt-independent activation of β-catenin/TCF signaling

Inhibition of Wnt/β-catenin/T-cell factor (TCF) signaling induces proliferation of mesenchymal stem cells and/or suppresses their differentiation into osteoblasts (OBs). Osteolysis in multiple myeloma (MM) is related to the suppression of canonical Wnt signaling caused by DKK1, a soluble inhibitor o...

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Detalhes bibliográficos
Main Authors: Qiang, Ya-Wei, Hu, Bo, Chen, Yu, Zhong, Ying, Shi, Bingyin, Barlogie, Bart, Shaughnessy, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676089/
https://ncbi.nlm.nih.gov/pubmed/19196662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-174300
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