TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes

During canonical Wnt signalling, the activity of nuclear β‐catenin is largely mediated by the TCF/LEF family of transcription factors. To challenge this view, we used the CRISPR/Cas9 genome editing approach to generate HEK 293T cell clones lacking all four TCF/LEF genes. By performing unbiased whole...

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Detaylı Bibliyografya
Yayımlandı:EMBO J
Asıl Yazarlar: Doumpas, Nikolaos, Lampart, Franziska, Robinson, Mark D, Lentini, Antonio, Nestor, Colm E, Cantù, Claudio, Basler, Konrad
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331726/
https://ncbi.nlm.nih.gov/pubmed/30425074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798873
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