Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain

We investigated the impact of rhesus macaque (RM) B-cell depletion before inoculation with the isolate SIVsmmD215. Seven RMs were treated every 3 weeks with 50 mg/kg of an anti-CD20 antibody (rituximab) starting 7 days before inoculation for 2 (n = 4) and 5 (n = 3) months. Four control animals recei...

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Main Authors: Gaufin, Thaidra, Gautam, Rajeev, Kasheta, Melissa, Ribeiro, Ruy, Ribka, Erin, Barnes, Mary, Pattison, Melissa, Tatum, Coty, MacFarland, Jeanne, Montefiori, David, Kaur, Amitinder, Pandrea, Ivona, Apetrei, Cristian
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2009
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676085/
https://ncbi.nlm.nih.gov/pubmed/19168789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-177741
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