Simian Immunodeficiency Virus SIVrcm, a Unique CCR2-Tropic Virus, Selectively Depletes Memory CD4(+) T Cells in Pigtailed Macaques through Expanded Coreceptor Usage In Vivo

Simian immunodeficiency virus SIVrcm, which naturally infects red-capped mangabeys (RCMs), is the only SIV that uses CCR2 as its main coreceptor due to the high frequency of a CCR5 deletion in RCMs. We investigated the dynamics of SIVrcm infection to identify specific pathogenic mechanisms associate...

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Detalhes bibliográficos
Main Authors: Gautam, Rajeev, Gaufin, Thaidra, Butler, Isolde, Gautam, Aarti, Barnes, Mary, Mandell, Daniel, Pattison, Melissa, Tatum, Coty, Macfarland, Jeanne, Monjure, Christopher, Marx, Preston A., Pandrea, Ivona, Apetrei, Cristian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715763/
https://ncbi.nlm.nih.gov/pubmed/19493994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00444-09
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