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Cdc37 Regulates Ryk Signaling by Stabilizing the Cleaved Ryk Intracellular Domain
Ryk is a Wnt receptor that plays an important role in neurogenesis, neurite outgrowth, and axon guidance. We have reported that the Ryk receptor is cleaved by γ-secretase and that its intracellular domain (ICD) translocates to the nucleus upon Wnt stimulation. Cleavage of Ryk and its ICD is importan...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676025/ https://ncbi.nlm.nih.gov/pubmed/19269974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900207200 |
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