Neutral Cysteine Protease Bleomycin Hydrolase Is Essential for the Breakdown of Deiminated Filaggrin into Amino Acids

Filaggrin is a component of the cornified cell envelope and the precursor of free amino acids acting as a natural moisturizing factor in the stratum corneum. Deimination is critical for the degradation of filaggrin into free amino acids. In this study, we tried to identify the enzyme(s) responsible...

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Autores principales: Kamata, Yayoi, Taniguchi, Aya, Yamamoto, Mami, Nomura, Junko, Ishihara, Kazuhiko, Takahara, Hidenari, Hibino, Toshihiko, Takeda, Atsushi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676013/
https://ncbi.nlm.nih.gov/pubmed/19286660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807908200
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