Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein

Rheb G-protein plays critical roles in the TSC/Rheb/mTOR signaling pathway by activating mTORC1. The activation of mTORC1 by Rheb can be faithfully reproduced in vitro by using mTORC1 immunoprecipitated by the use of anti-raptor antibody from mammalian cells starved for nutrients. The low in vitro k...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Sato, Tatsuhiro, Nakashima, Akio, Guo, Lea, Tamanoi, Fuyuhiko
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2009
נושאים:
Mechanisms of Signal Transduction
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676008/
https://ncbi.nlm.nih.gov/pubmed/19299511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809207200
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