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Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients

AIMS: The aims of this study were to develop a combined population pharmacokinetic model for both aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients and to identify to what extent the genetic polymorphisms of cytochrome P450 (CYP) enzymes contribute to the variabili...

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Detalhes bibliográficos
Main Authors: Kim, Jung-Ryul, Seo, Hyo-Bum, Cho, Joo-Youn, Kang, Do-Hyung, Kim, Yong Ku, Bahk, Won-Myong, Yu, Kyung-Sang, Shin, Sang-Goo, Kwon, Jun Soo, Jang, In-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675764/
https://ncbi.nlm.nih.gov/pubmed/19032724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03223.x
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