Limited Role of Murine ATM in Oncogene-Induced Senescence and p53-Dependent Tumor Suppression

Recent studies in human fibroblasts have provided a new general paradigm of tumor suppression according to which oncogenic signaling produces DNA damage and this, in turn, results in ATM/p53-dependent cellular senescence. Here, we have tested this model in a variety of murine experimental systems. O...

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Bibliografski detalji
Glavni autori: Efeyan, Alejo, Murga, Matilde, Martinez-Pastor, Barbara, Ortega-Molina, Ana, Soria, Rebeca, Collado, Manuel, Fernandez-Capetillo, Oscar, Serrano, Manuel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675057/
https://ncbi.nlm.nih.gov/pubmed/19421407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005475
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