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Limited Role of Murine ATM in Oncogene-Induced Senescence and p53-Dependent Tumor Suppression
Recent studies in human fibroblasts have provided a new general paradigm of tumor suppression according to which oncogenic signaling produces DNA damage and this, in turn, results in ATM/p53-dependent cellular senescence. Here, we have tested this model in a variety of murine experimental systems. O...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2675057/ https://ncbi.nlm.nih.gov/pubmed/19421407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005475 |
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