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Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons

Persistent plastic changes to the intrinsic excitability of neurons have substantial implications for computational processing within the CNS. We have identified and characterized a novel long-lasting form of intrinsic plasticity in hippocampal CA3 pyramidal cells. Although the patterns of action po...

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Detalhes bibliográficos
Main Authors: Brown, Jon T, Randall, Andrew D
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674996/
https://ncbi.nlm.nih.gov/pubmed/19171653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.167007
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