Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures

BACKGROUND: A restrictive chromatin state has been thought to be operant in the pathophysiology of schizophrenia. Our objective was to ascertain whether differences exist between baseline levels of a repressive chromatin mark such as dimethylated lysine 9 of histone 3 (H3K9me2) in patients with schi...

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Autores principales: Gavin, David P., Rosen, Cherise, Chase, Kayla, Grayson, Dennis R., Tun, Nguwah, Sharma, Rajiv P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Canadian Medical Association 2009
Materias:
Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674978/
https://ncbi.nlm.nih.gov/pubmed/19448855
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