Alternative Induction of Meiotic Recombination From Single-Base Lesions of DNA Deaminases

Meiotic recombination enhances genetic diversity as well as ensures proper segregation of homologous chromosomes, requiring Spo11-initiated double-strand breaks (DSBs). DNA deaminases act on regions of single-stranded DNA and deaminate cytosine to uracil (dU). In the immunoglobulin locus, this lesio...

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Autori principali: Pauklin, Siim, Burkert, Julia S., Martin, Julie, Osman, Fekret, Weller, Sandra, Boulton, Simon J., Whitby, Matthew C., Petersen-Mahrt, Svend K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Genetics Society of America 2009
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Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674839/
https://ncbi.nlm.nih.gov/pubmed/19237686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.101683
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