Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes

BACKGROUND: Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms. OBJECTIVE: To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa...

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Hlavní autoři: Yatabe, T, Mochizuki, S, Takizawa, M, Chijiiwa, M, Okada, A, Kimura, T, Fujita, Y, Matsumoto, H, Toyama, Y, Okada, Y
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2009
Témata:
Basic and Translational Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674548/
https://ncbi.nlm.nih.gov/pubmed/18662930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2007.086884
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