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Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis
The extracellular matrix of articular cartilage is structurally specialized for efficient absorption of mechanical impact. In particular, giant aggregates of the large chondroitin sulfate proteoglycan, aggrecan, with the glycosaminoglycan, hyaluronan, allow cartilage to resist compressive load. Prot...
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| Publicado no: | Biochem J |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5525052/ https://ncbi.nlm.nih.gov/pubmed/26657033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151072 |
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