Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes

BACKGROUND: Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms. OBJECTIVE: To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa...

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Autors principals: Yatabe, T, Mochizuki, S, Takizawa, M, Chijiiwa, M, Okada, A, Kimura, T, Fujita, Y, Matsumoto, H, Toyama, Y, Okada, Y
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2009
Matèries:
Basic and Translational Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674548/
https://ncbi.nlm.nih.gov/pubmed/18662930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2007.086884
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