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Predicting the Energetics of Conformational Fluctuations in Proteins from Sequence: A Strategy for Profiling the Proteome
The abundance of dynamic and disordered regions in proteins suggests that structural determinants alone may not be sufficient to describe function. Instead descriptors which account for the dynamic features of the energy landscape populated by the protein ensemble may be required. Here we show that...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674280/ https://ncbi.nlm.nih.gov/pubmed/19000815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.08.016 |
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