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Predicting the Energetics of Conformational Fluctuations in Proteins from Sequence: A Strategy for Profiling the Proteome

The abundance of dynamic and disordered regions in proteins suggests that structural determinants alone may not be sufficient to describe function. Instead descriptors which account for the dynamic features of the energy landscape populated by the protein ensemble may be required. Here we show that...

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Autori principali: Gu, Jenny, Hilser, Vincent J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674280/
https://ncbi.nlm.nih.gov/pubmed/19000815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.08.016
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