Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

BACKGROUND: GATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on...

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Main Authors: Maneechotesuwan, Kittipong, Yao, Xin, Ito, Kazuhiro, Jazrawi, Elen, Usmani, Omar S., Adcock, Ian M., Barnes, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674207/
https://ncbi.nlm.nih.gov/pubmed/19436703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1000076
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