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GNAI2 and Regulators of G protein Signaling as a potential Noonan Syndrome mechanism

Noonan syndrome (NS OMIM 163950) is a relatively common autosomal dominant developmental disorder characterized by short stature, specific facial features, and congenital cardiac anomalies. Approximately 50–66% of cases have defined mutations in the K-ras/Raf/MEK/ERK pathway that lead to constitutiv...

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Библиографические подробности
Главные авторы: Huang, Xinyan, Fu, Ying, Charbeneau, Raelene A., Neubig, Richard R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674134/
https://ncbi.nlm.nih.gov/pubmed/19282110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mehy.2009.01.040
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