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Basic pharmacodynamic models for agents that alter the lifespan distribution of natural cells

A new class of basic indirect pharmacodynamic models for agents that alter the loss of natural cells based on a lifespan concept are presented. The lifespan indirect response (LIDR) models assume that cells (R) are produced at a constant rate (k(in)), survive during a certain duration T(R), and fina...

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Hlavní autoři: Krzyzanski, Wojciech, Perez-Ruixo, Juan Jose, Vermeulen, An
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673548/
https://ncbi.nlm.nih.gov/pubmed/18551354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-008-9092-6
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