Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment

Interactions between tumor and immune cells either enhance or inhibit cancer progression. We show here that Stat3 signaling within the tumor microenvironment induces a pro-carcinogenic cytokine, IL-23, while inhibiting a central anti-carcinogenic cytokine, IL-12, thereby shifting the balance of tumo...

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Bibliographic Details
Main Authors: Kortylewski, Marcin, Xin, Hong, Kujawski, Maciej, Lee, Heehyoung, Liu, Yong, Harris, Timothy, Drake, Charles, Pardoll, Drew, Yu, Hua
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673504/
https://ncbi.nlm.nih.gov/pubmed/19185846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.12.018
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