Differential Presentation of Protein Interaction Surfaces on the Androgen Receptor Defines the Pharmacological Actions of Bound Ligands

The pharmacological activity of different nuclear receptor (NR) ligands is reflected by their impact on receptor structure. Thus, we asked whether differential presentation of protein-protein interaction surfaces on the androgen receptor (AR), a surrogate assay of receptor conformation, could be use...

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Autori principali: Norris, John David, Joseph, James David, Sherk, Andrea Barreto, Juzumiene, Dalia, Turnbull, Philip Stewart, Rafferty, Stephen William, Cui, Huaxia, Anderson, Erin, Fan, Daju, Dye, Delita Arnelle, Deng, Xiang, Kazmin, Dmitri, Chang, Ching-Yi, Willson, Tim Mark, McDonnell, Donald Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673463/
https://ncbi.nlm.nih.gov/pubmed/19389631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.01.016
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