KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli

The 5-formyluracil (5-foU), a major mutagenic oxidative damage of thymine, is removed from DNA by Nth, Nei and MutM in Escherichia coli. However, DNA polymerases can also replicate past the 5-foU by incorporating C and G opposite the lesion, although the mechanism of correction of the incorporated b...

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Hlavní autoři: Zhang-Akiyama, Qiu-Mei, Morinaga, Hironobu, Kikuchi, Masahiro, Yonekura, Shin-Ichiro, Sugiyama, Hiroshi, Yamamoto, Kazuo, Yonei, Shuji
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673420/
https://ncbi.nlm.nih.gov/pubmed/19223326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp057
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