Inactivation of KsgA, a 16S rRNA Methyltransferase, Causes Vigorous Emergence of Mutants with High-Level Kasugamycin Resistance

The methyltransferases RsmG and KsgA methylate the nucleotides G535 (RsmG) and A1518 and A1519 (KsgA) in 16S rRNA, and inactivation of the proteins by introducing mutations results in acquisition of low-level resistance to streptomycin and kasugamycin, respectively. In a Bacillus subtilis strain har...

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Bibliographische Detailangaben
Hauptverfasser: Ochi, Kozo, Kim, Ji-Yun, Tanaka, Yukinori, Wang, Guojun, Masuda, Kenta, Nanamiya, Hideaki, Okamoto, Susumu, Tokuyama, Shinji, Adachi, Yoshikazu, Kawamura, Fujio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612157/
https://ncbi.nlm.nih.gov/pubmed/19001112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00873-08
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