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Targeting individual subunits of the FokI restriction endonuclease to specific DNA strands

Many restriction endonucleases are dimers that act symmetrically at palindromic DNA sequences, with each active site cutting one strand. In contrast, FokI acts asymmetrically at a non-palindromic sequence, cutting ‘top’ and ‘bottom’ strands 9 and 13 nucleotides downstream of the site. FokI is a mono...

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Détails bibliographiques
Auteurs principaux: Sanders, Kelly L., Catto, Lucy E., Bellamy, Stuart R. W., Halford, Stephen E.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673415/
https://ncbi.nlm.nih.gov/pubmed/19223323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp046
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