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Targeting individual subunits of the FokI restriction endonuclease to specific DNA strands
Many restriction endonucleases are dimers that act symmetrically at palindromic DNA sequences, with each active site cutting one strand. In contrast, FokI acts asymmetrically at a non-palindromic sequence, cutting ‘top’ and ‘bottom’ strands 9 and 13 nucleotides downstream of the site. FokI is a mono...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673415/ https://ncbi.nlm.nih.gov/pubmed/19223323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp046 |
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