Biphasic Activation of p38MAPK Suggests That Apoptosis Is a Downstream Event in Pemphigus Acantholysis

In pemphigus vulgaris and pemphigus foliaceus (PF), autoantibodies against desmoglein-3 and desmoglein-1 induce epidermal cell detachment (acantholysis) and blistering. Activation of keratinocyte intracellular signaling pathways is emerging as an important component of pemphigus IgG-mediated acantho...

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Hlavní autoři: Lee, Hua En, Berkowitz, Paula, Jolly, Puneet S., Diaz, Luis A., Chua, Michael P., Rubenstein, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673318/
https://ncbi.nlm.nih.gov/pubmed/19270308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808204200
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