Optimizing pH Response of Affinity between Protein G and IgG Fc: HOW ELECTROSTATIC MODULATIONS AFFECT PROTEIN-PROTEIN INTERACTIONS

Protein-protein interaction in response to environmental conditions enables sophisticated biological and biotechnological processes. Aiming toward the rational design of a pH-sensitive protein-protein interaction, we engineered pH-sensitive mutants of streptococcal protein G B1, a binder to the IgG...

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Bibliografiske detaljer
Main Authors: Watanabe, Hideki, Matsumaru, Hiroyuki, Ooishi, Ayako, Feng, YanWen, Odahara, Takayuki, Suto, Kyoko, Honda, Shinya
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673305/
https://ncbi.nlm.nih.gov/pubmed/19269963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809236200
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