Copper binding to the prion protein: Structural implications of four identical cooperative binding sites

Evidence is growing to support a functional role for the prion protein (PrP) in copper metabolism. Copper ions appear to bind to the protein in a highly conserved octapeptide repeat region (sequence PHGGGWGQ) near the N terminus. To delineate the site and mode of binding of Cu(II) to the PrP, the co...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Viles, John H., Cohen, Fred E., Prusiner, Stanley B., Goodin, David B., Wright, Peter E., Dyson, H. Jane
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26733/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051591/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2042
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