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Copper-catalyzed oxidation of the recombinant SHa(29–231) prion protein

Metal-catalyzed oxidation may result in structural damage to proteins and has been implicated in aging and disease, including neurological disorders such as Alzheimer's disease and amyotrophic lateral sclerosis. The selective modification of specific amino acid residues with high metal ion affi...

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Detalhes bibliográficos
Main Authors: Requena, Jesús R., Groth, Darlene, Legname, Giuseppe, Stadtman, Earl R., Prusiner, Stanley B., Levine, Rodney L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC34641/
https://ncbi.nlm.nih.gov/pubmed/11404462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121190898
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