Intracellular Trafficking of Presenilin 1 Is Regulated by β-Amyloid Precursor Protein and Phospholipase D1

Excessive accumulation of β-amyloid peptides in the brain is a major cause for the pathogenesis of Alzheimer disease. β-Amyloid is derived from β-amyloid precursor protein (APP) through sequential cleavages by β- and γ-secretases, whose enzymatic activities are tightly controlled by subcellular loca...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Liu, Yun, Zhang, Yun-wu, Wang, Xin, Zhang, Han, You, Xiaoqing, Liao, Francesca-Fang, Xu, Huaxi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Membrane Transport, Structure, Function, and Biogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673283/
https://ncbi.nlm.nih.gov/pubmed/19276086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808497200
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