The Second Transmembrane Domain of the Human Type 1 Angiotensin II Receptor Participates in the Formation of the Ligand Binding Pocket and Undergoes Integral Pivoting Movement during the Process of Receptor Activation

The octapeptide hormone angiotensin II (AngII) exerts a wide variety of cardiovascular effects through the activation of the angiotensin II type-1 (AT(1)) receptor, which belongs to the G protein-coupled receptor superfamily. Like other G protein-coupled receptors, the AT(1) receptor possesses seven...

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Bibliographische Detailangaben
Hauptverfasser: Domazet, Ivana, Holleran, Brian J., Martin, Stéphane S., Lavigne, Pierre, Leduc, Richard, Escher, Emanuel, Guillemette, Gaétan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673261/
https://ncbi.nlm.nih.gov/pubmed/19276075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808113200
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