Effects of Combined Phosphorylation at Ser-617 and Ser-1179 in Endothelial Nitric-oxide Synthase on EC(50)(Ca(2+)) Values for Calmodulin Binding and Enzyme Activation

We have investigated the possible biochemical basis for enhancements in NO production in endothelial cells that have been correlated with agonist- or shear stress-evoked phosphorylation at Ser-1179. We have found that a phosphomimetic substitution at Ser-1179 doubles maximal synthase activity, parti...

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Main Authors: Tran, Quang-Kim, Leonard, Jared, Black, D. J., Nadeau, Owen W., Boulatnikov, Igor G., Persechini, Anthony
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673258/
https://ncbi.nlm.nih.gov/pubmed/19251696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806205200
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