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Identification of functionally important residues/domains in membrane proteins using an evolutionary approach coupled with systematic mutational analysis
Structure-function studies of membrane proteins present a unique challenge to researchers due to the numerous technical difficulties associated with their expression, purification and structural characterization. In the absence of structural information, rational identification of putative functiona...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673147/ https://ncbi.nlm.nih.gov/pubmed/18839354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-59745-523-7_17 |
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