A Pilot Study to Evaluate the Safety and Clinical Outcomes of Vaccination with Recombinant CEA-MUC-1-TRICOM (PANVAC) Poxviral-based Vaccines in Patients with Metastatic Carcinoma

PURPOSE: Poxviral vectors have a proven safety record and can be used to incorporate multiple transgenes. Prior clinical trials with poxviral vaccines have shown that immunologic tolerance to self-antigens can be broken. Carcinoembryonic antigen (CEA) and MUC-1 are overexpressed in a substantial pro...

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Main Authors: Gulley, James L., Arlen, Philip M., Tsang, Kwong-Yok, Yokokawa, Junko, Palena, Claudia, Poole, Diane J., Remondo, Cinzia, Cereda, Vittore, Jones, Jacquin L., Pazdur, Mary P., Higgins, Jack P., Hodge, James W., Steinberg, Seth M., Kotz, Herbert, Dahut, William L., Schlom, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673097/
https://ncbi.nlm.nih.gov/pubmed/18483372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0126
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