A conformational switch in the DiGIR1 ribozyme involved in release and folding of the downstream I-DirI mRNA

DiGIR1 is a group I-like cleavage ribozyme found as a structural domain within a nuclear twin-ribozyme group I intron. DiGIR1 catalyzes cleavage by branching at an Internal Processing Site (IPS) leading to formation of a lariat cap at the 5′-end of the 3′-cleavage product. The 3′-cleavage product is...

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Bibliographic Details
Main Authors: Nielsen, Henrik, Einvik, Christer, Lentz, Thomas E., Hedegaard, Mads Marquardt, Johansen, Steinar D.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673072/
https://ncbi.nlm.nih.gov/pubmed/19329537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.669209
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