Molecular modelling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes

Twin-ribozyme introns contain a branching ribozyme (GIR1) followed by a homing endonuclease (HE) encoding sequence embedded in a peripheral domain of a group I splicing ribozyme (GIR2). GIR1 catalyses the formation of a lariat with 3 nt in the loop, which caps the HE mRNA. GIR1 is structurally relat...

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Autori principali: Beckert, Bertrand, Nielsen, Henrik, Einvik, Christer, Johansen, Steinar D, Westhof, Eric, Masquida, Benoît
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2219692/
https://ncbi.nlm.nih.gov/pubmed/18219270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.4
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