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Molecular modelling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes
Twin-ribozyme introns contain a branching ribozyme (GIR1) followed by a homing endonuclease (HE) encoding sequence embedded in a peripheral domain of a group I splicing ribozyme (GIR2). GIR1 catalyses the formation of a lariat with 3 nt in the loop, which caps the HE mRNA. GIR1 is structurally relat...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2219692/ https://ncbi.nlm.nih.gov/pubmed/18219270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.4 |
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