Lef1 Haploinsufficient Mice Display a Low Turnover and Low Bone Mass Phenotype in a Gender- and Age-Specific Manner

We investigated the role of Lef1, one of the four transcription factors that transmit Wnt signaling to the genome, in the regulation of bone mass. Microcomputed tomographic analysis of 13- and 17-week-old mice revealed significantly reduced trabecular bone mass in Lef1(+/−) females compared to litte...

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Autori principali: Noh, Tommy, Gabet, Yankel, Cogan, Jon, Shi, Yunfan, Tank, Archana, Sasaki, Tomoyo, Criswell, Braden, Dixon, Alexis, Lee, Christopher, Tam, Joseph, Kohler, Thomas, Segev, Eran, Kockeritz, Lisa, Woodgett, James, Müller, Ralph, Chai, Yang, Smith, Elisheva, Bab, Itai, Frenkel, Baruch
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673053/
https://ncbi.nlm.nih.gov/pubmed/19412553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005438
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