Lef1 Haploinsufficient Mice Display a Low Turnover and Low Bone Mass Phenotype in a Gender- and Age-Specific Manner

We investigated the role of Lef1, one of the four transcription factors that transmit Wnt signaling to the genome, in the regulation of bone mass. Microcomputed tomographic analysis of 13- and 17-week-old mice revealed significantly reduced trabecular bone mass in Lef1(+/−) females compared to litte...

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Detalhes bibliográficos
Main Authors: Noh, Tommy, Gabet, Yankel, Cogan, Jon, Shi, Yunfan, Tank, Archana, Sasaki, Tomoyo, Criswell, Braden, Dixon, Alexis, Lee, Christopher, Tam, Joseph, Kohler, Thomas, Segev, Eran, Kockeritz, Lisa, Woodgett, James, Müller, Ralph, Chai, Yang, Smith, Elisheva, Bab, Itai, Frenkel, Baruch
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673053/
https://ncbi.nlm.nih.gov/pubmed/19412553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005438
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