Design and Activity of a Murine and Humanized anti-CEACAM6 scFv in the Treatment of Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with surgery the only curative modality for localized disease; gemcitabine with or without erlotinib remains standard therapy for unresectable or metastatic disease. CEACAM6 is over-expressed in human PDA independent of stage or grade, and c...

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Detalhes bibliográficos
Main Authors: Riley, Christopher J., Engelhardt, Kevin P., Saldanha, Jose W., Qi, Wenqing, Cooke, Laurence S., Zhu, Yingting, Narayan, Satya T., Shakalya, Kishore, Croce, Kimiko Della, Georgiev, Ivan G., Nagle, Raymond B., Garewal, Harinder, Von Hoff, Daniel D., Mahadevan, Daruka
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672909/
https://ncbi.nlm.nih.gov/pubmed/19244123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2707
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