Role of Glutaredoxin-Mediated Protein S-Glutathionylation in Cellular Nitroglycerin Tolerance

We hypothesize that nitroglycerin (NTG) causes direct oxidation of multiple cellular sulfhydryl (SH) proteins and that manipulation of SH redox status affects NTG tolerance. In LLC-PK1 cells, we found that nitrate tolerance, as indicated by cGMP accumulation toward NTG, was accompanied by increased...

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Bibliografiske detaljer
Main Authors: Tsou, Pei-Suen, Addanki, Vamsi, Haas, Jessica A., Page, Nathaniel A., Fung, Ho-Leung
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Pharmacology and Experimental Therapeutics 2009
Fag:
Cardiovascular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672869/
https://ncbi.nlm.nih.gov/pubmed/19223666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.149997
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